This is a treatment commonly used in Multiple sclerosis and other known deasises such as Guillain-Barre syndrome. Possible Complications Complications are rare, but no procedure is completely free of risk. If you are planning to have plasmapheresis, your doctor will review a list of possible complications, which may include: •Anaphylaxis—a dangerous allergic reaction to the solutions used in plasma replacement, which usually starts with itching, wheezing, or a rash. •Mild allergic reaction to the procedure—may cause fever, chills, or rash •Infection •Bleeding •Drop in blood pressure •Bruising or swelling Plasmapheresis may not be appropriate for people with certain clotting disorders. Call Your Doctor After you leave the hospital, contact your doctor if any of the following occurs: •Excessive bruising, bleeding, or swelling at the needle insertion sites •Signs of infection, including fever and chills •Seizures •Excessive itching or rash •Nausea and/or vomiting •Pai...